Pedro Luis De la Torre Márquez
Position: PhD (c) in Applied Sciences.
Academic Degree: Chemist. (Universidad del Atlántico-Colombia)
Email: pdelatorre@utalca.cl
My experimental research interests are centered in heterocyclic chemistry with special emphasis in the development of novel building block precursors, synthetic methods, “green procedures” using microwave irradiation as an unconventional heating source.
Identification of organic compounds by Nuclear Magnetic Resonance Spectroscopy (NMR) and Mass Spectrometry.
Other research efforts are focused on the computational design and synthesis of heterocyclic compounds and their application as selective acetyl cholinesterase (AChE) inhibitors, study of protein-ligand interactions by molecular docking simulations, molecular dynamics and other bioinformatics tools.
Research areas
Organic synthesis
Study of fluorescent properties of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroaryl-acrylonitriles derivatives and their application as fluorescent sensors for the selective detection and quantification of intracellular bio-thiols as cysteine (Cys), glutathione (GSH) and homocysteine (Hcy), and as probes in the image creation of intracellular fluorescence of thiols in cells SH-SY5Y of human neuroblastoma.
Study of a novel class of selective Acetylcholinesterase Inhibitors: synthesis and evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroaryl-acrylonitriles.
Estimation of the relative binding free energy of the Ligand–Protein complexes using MM-GBSA (MM, molecular mechanics; GB, generalized Born; SA, surface area) methods.
De novo design of AChE inhibitors.
Chemo specific synthesis of amine derivatives from 2-amino-4,6-dichloropyrimidine-5-carbaldehyde under Microwave-assisted conditions and their application as Acetylcholinesterase inhibitors.
Research Funding
Laboratory of organic synthesis and biological activity (LSO-Act-Bio) of Chemical Institute of Natural Resources (UTALCA)
Recent Publications
A novel class of selective Acetylcholinesterase Inhibitors: synthesis and evaluation of (E)-2-(Benzo[d]thiazol-2-yl)-3-heteroaryl-acrylonitriles. Molecules, 17, 12072-12085, 2012.
Rodrigo Recabarren Hurtado
Position: PhD Student in Applied Sciences Program
Academic Degree: BS in Chemistry (PUC)
Email: rhrecaba@gmail.com
My current area of work is the study of chromophores which act as probes to sense transmembrane potentials in cells. The modelling of these chomophores is made by means of quantum mechanics, molecular dynamics, and hybrid approaches such as QM/MM methodologies. The goals of the research are focused in characterizing the location of the membrane probe at different electronic states inside the lipid bilayer, analysis of spectroscopic properties such as absorption and emission spectra, the influence of applied electric fields over the membrane and fluorophore properties.
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David Mauricio Ramírez Sánchez
Position: PhD (c) in Applied Sciences
Academic Degrees: BS in Chemistry (Universidad Distrital Francisco José de Caldas – Colombia – 2009); Pharmaceutical Chemistry (Universidad Nacional de Colombia – Colombia – 2012)
Email: davramirez@utalca.cl – damach.david@gmail.com
My research field is Biophysics and Structural Bioinformatics. I am currently focusing in the rational drug desing targeting Potassium Channels. The molecular modeling of these channels is made by molecular mechanics simulations like molecular dynamics. The goals of the research are to study the intracellular domains in which the potential drugs interact with the potassium channels, as well as design new blockers site-directed to the intracellular domain, from site and binding mode of the blockers already described; thus establishing the most probable binding site and evaluating their interaction in biological systems.
Recent Publications
- Kiper A., Rinné S., rolfes C., Ramírez D., Seebohm G., Netter M., González W., Decher N.. Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fribrillation and obstructive sleep apnea? Pflügers Archiv – European Journal of Physiology. 2014. Under revision : No. PAEJ-D-14-00339R1
- González W., Valdebenito B., Caballero J., Riadi G., Riedelsberger J., Martínez G., Ramírez D., Zuñiga L., Sepúlveda F., Dreyer I., Janta M., Becker D. K2P channels in plants and animals. Pflügers Archiv – European Journal of Physiology. 2014. 1-14. doi: 10.1007/s00424-014-1638-4.
- Angélica Sabogal-Arango, George E. Barreto, David Ramírez-Sánchez, Juan González-Mendoza, Viviana Barreto, Ludis Morales and Janneth González. Computational insights of the interaction among Sea anemones Neurotonxins and Kv1.3 Channels. Bioinformatics and Biology insigths, 2014:8 73-81 doi: 10.4137/BBI.S13403.