❮ ❯

	Selected Publications
	Rueda, A. J. V., Conteville, L., Pantano, S., & González, W. (2022). Women in bioinformatics & data science - Latin America. MethodsX, 9, 101907.
	Arévalo, B., Bedoya, M., Kiper, A. K., Vergara, F., Ramírez, D., Mazola, Y., Bustos, D., Zúñiga, R., Cikutovic, R., Cayo, A., Rinné, S., Ramirez-Apan, M. T., Sepúlveda, F. V., Cerda, O., López-Collazo, E., Decher, N., Zúñiga, L., Gutierrez, M., & González, W. (2022). Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. Journal of medicinal chemistry, 65(22), 15014–15027.
	Zúñiga, L., Cayo, A., González, W., Vilos, C., & Zúñiga, R. (2022). Potassium Channels as a Target for Cancer Therapy: Current Perspectives. OncoTargets and therapy, 15, 783–797.
	Zúñiga, R., Mancilla, D., Rojas, T., Vergara, F., González, W., Catalán, M. A., & Zúñiga, L. (2022). A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons. Biology, 11(8), 1097.
	Mazola, Y., Márquez Montesinos, J. C. E., Ramírez, D., Zúñiga, L., Decher, N., Ravens, U., Yarov-Yarovoy, V., & González, W. (2022). Common Structural Pattern for Flecainide Binding in Atrial-Selective Kv1.5 and Nav1.5 Channels: A Computational Approach. Pharmaceutics, 14(7), 1356.
	Valdés-Jiménez, A., Jiménez-González, D., Kiper, A. K., Rinné, S., Decher, N., González, W., Reyes-Parada, M., & Núñez-Vivanco, G. (2022). A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels. Frontiers in pharmacology, 13, 855792. https://doi.org/10.3389/fphar.2022.855792
	Ramirez, A. E., Fernández-Pérez, E. J., Olivos, N., Burgos, C. F., Boopathi, S., Armijo-Weingart, L., Pacheco, C. R., González, W., & Aguayo, L. G. (2021). The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine. International journal of molecular sciences, 22(24), 13253. https://doi.org/10.3390/ijms222413253
	González-Avendaño, M., Zúñiga-Almonacid, S., Silva, I., Lavanderos, B., Robinson, F., Rosales-Rojas, R., Durán-Verdugo, F., González, W., Cáceres, M., Cerda, O., & Vergara-Jaque, A. (2021). PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data. Frontiers in molecular biosciences, 8, 701477. https://doi.org/10.3389/fmolb.2021.701477
	Ramírez, D., Mejia-Gutierrez, M., Insuasty, B., Rinné, S., Kiper, A. K., Platzk, M., Müller, T., Decher, N., Quiroga, J., De-la-Torre, P., & González, W. (2021). 5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis. Molecules (Basel, Switzerland), 26(13), 3897. https://doi.org/10.3390/molecules26133897
	Kiper, A. K., Bedoya, M., Stalke, S., Marzian, S., Ramírez, D., de la Cruz, A., Peraza, D. A., Vera-Zambrano, A., Márquez Montesinos, J. C. E., Arévalo Ramos, B. A., Rinné, S., Gonzalez, T., Valenzuela, C., Gonzalez, W., & Decher, N. (2021). Identification of a critical binding site for local anaesthetics in the side pockets of Kv 1 channels. British journal of pharmacology, 178(15), 3034–3048. https://doi.org/10.1111/bph.15480
	Solorza, J., Oliva, C. A., Castillo, K., Amestica, G., Maldifassi, M. C., López-Cortés, X. A., Barra, R., Stehberg, J., Piesche, M., Sáez-Briones, P., González, W., Arenas-Salinas, M., & Mariqueo, T. A. (2021). Effects of Interleukin-1β in Glycinergic Transmission at the Central Amygdala. Frontiers in pharmacology, 12, 613105. https://doi.org/10.3389/fphar.2021.613105
	Riedelsberger, J., Miller, J. K., Valdebenito-Maturana, B., Piñeros, M. A., González, W., & Dreyer, I. (2021). Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation. International journal of molecular sciences, 22(4), 1892. https://doi.org/10.3390/ijms22041892
	Decher, N., Rinné, S., Bedoya, M., Gonzalez, W., & Kiper, A. K. (2021). Molecular Pharmacology of K2P Potassium Channels. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 55(S3), 87–107. https://doi.org/10.33594/000000339
	González-Sanmiguel, J., Burgos, C. F., Bascuñán, D., Fernández-Pérez, E. J., Riffo-Lepe, N., Boopathi, S., Fernández-Pérez, A., Bobadilla-Azócar, C., González, W., Figueroa, M., Vicente, B., & Aguayo, L. G. (2020). Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade. ACS chemical neuroscience, 11(19), 3064–3076. https://doi.org/10.1021/acschemneuro.0c00414
	Zúñiga, R., Concha, G., Cayo, A., Cikutović-Molina, R., Arevalo, B., González, W., Catalán, M. A., & Zúñiga, L. (2020). Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 129, 110383. https://doi.org/10.1016/j.biopha.2020.110383

Selected Publications

Rueda, A. J. V., Conteville, L., Pantano, S., & González, W. (2022). Women in bioinformatics & data science - Latin America. MethodsX, 9, 101907.

Arévalo, B., Bedoya, M., Kiper, A. K., Vergara, F., Ramírez, D., Mazola, Y., Bustos, D., Zúñiga, R., Cikutovic, R., Cayo, A., Rinné, S., Ramirez-Apan, M. T., Sepúlveda, F. V., Cerda, O., López-Collazo, E., Decher, N., Zúñiga, L., Gutierrez, M., & González, W. (2022). Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. Journal of medicinal chemistry, 65(22), 15014–15027.

Zúñiga, L., Cayo, A., González, W., Vilos, C., & Zúñiga, R. (2022). Potassium Channels as a Target for Cancer Therapy: Current Perspectives. OncoTargets and therapy, 15, 783–797.

Zúñiga, R., Mancilla, D., Rojas, T., Vergara, F., González, W., Catalán, M. A., & Zúñiga, L. (2022). A Direct Interaction between Cyclodextrins and TASK Channels Decreases the Leak Current in Cerebellar Granule Neurons. Biology, 11(8), 1097.

Mazola, Y., Márquez Montesinos, J. C. E., Ramírez, D., Zúñiga, L., Decher, N., Ravens, U., Yarov-Yarovoy, V., & González, W. (2022). Common Structural Pattern for Flecainide Binding in Atrial-Selective Kv1.5 and Nav1.5 Channels: A Computational Approach. Pharmaceutics, 14(7), 1356.

Valdés-Jiménez, A., Jiménez-González, D., Kiper, A. K., Rinné, S., Decher, N., González, W., Reyes-Parada, M., & Núñez-Vivanco, G. (2022). A New Strategy for Multitarget Drug Discovery/Repositioning Through the Identification of Similar 3D Amino Acid Patterns Among Proteins Structures: The Case of Tafluprost and its Effects on Cardiac Ion Channels. Frontiers in pharmacology, 13, 855792. https://doi.org/10.3389/fphar.2022.855792

Ramirez, A. E., Fernández-Pérez, E. J., Olivos, N., Burgos, C. F., Boopathi, S., Armijo-Weingart, L., Pacheco, C. R., González, W., & Aguayo, L. G. (2021). The Stimulatory Effects of Intracellular α-Synuclein on Synaptic Transmission Are Attenuated by 2-Octahydroisoquinolin-2(1H)-ylethanamine. International journal of molecular sciences, 22(24), 13253. https://doi.org/10.3390/ijms222413253

González-Avendaño, M., Zúñiga-Almonacid, S., Silva, I., Lavanderos, B., Robinson, F., Rosales-Rojas, R., Durán-Verdugo, F., González, W., Cáceres, M., Cerda, O., & Vergara-Jaque, A. (2021). PPI-MASS: An Interactive Web Server to Identify Protein-Protein Interactions From Mass Spectrometry-Based Proteomics Data. Frontiers in molecular biosciences, 8, 701477. https://doi.org/10.3389/fmolb.2021.701477

Ramírez, D., Mejia-Gutierrez, M., Insuasty, B., Rinné, S., Kiper, A. K., Platzk, M., Müller, T., Decher, N., Quiroga, J., De-la-Torre, P., & González, W. (2021). 5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis. Molecules (Basel, Switzerland), 26(13), 3897. https://doi.org/10.3390/molecules26133897

Kiper, A. K., Bedoya, M., Stalke, S., Marzian, S., Ramírez, D., de la Cruz, A., Peraza, D. A., Vera-Zambrano, A., Márquez Montesinos, J. C. E., Arévalo Ramos, B. A., Rinné, S., Gonzalez, T., Valenzuela, C., Gonzalez, W., & Decher, N. (2021). Identification of a critical binding site for local anaesthetics in the side pockets of Kv 1 channels. British journal of pharmacology, 178(15), 3034–3048. https://doi.org/10.1111/bph.15480

Solorza, J., Oliva, C. A., Castillo, K., Amestica, G., Maldifassi, M. C., López-Cortés, X. A., Barra, R., Stehberg, J., Piesche, M., Sáez-Briones, P., González, W., Arenas-Salinas, M., & Mariqueo, T. A. (2021). Effects of Interleukin-1β in Glycinergic Transmission at the Central Amygdala. Frontiers in pharmacology, 12, 613105. https://doi.org/10.3389/fphar.2021.613105

Riedelsberger, J., Miller, J. K., Valdebenito-Maturana, B., Piñeros, M. A., González, W., & Dreyer, I. (2021). Plant HKT Channels: An Updated View on Structure, Function and Gene Regulation. International journal of molecular sciences, 22(4), 1892. https://doi.org/10.3390/ijms22041892

Decher, N., Rinné, S., Bedoya, M., Gonzalez, W., & Kiper, A. K. (2021). Molecular Pharmacology of K2P Potassium Channels. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 55(S3), 87–107. https://doi.org/10.33594/000000339

González-Sanmiguel, J., Burgos, C. F., Bascuñán, D., Fernández-Pérez, E. J., Riffo-Lepe, N., Boopathi, S., Fernández-Pérez, A., Bobadilla-Azócar, C., González, W., Figueroa, M., Vicente, B., & Aguayo, L. G. (2020). Gabapentin Inhibits Multiple Steps in the Amyloid Beta Toxicity Cascade. ACS chemical neuroscience, 11(19), 3064–3076. https://doi.org/10.1021/acschemneuro.0c00414

Zúñiga, R., Concha, G., Cayo, A., Cikutović-Molina, R., Arevalo, B., González, W., Catalán, M. A., & Zúñiga, L. (2020). Withaferin A suppresses breast cancer cell proliferation by inhibition of the two-pore domain potassium (K2P9) channel TASK-3. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 129, 110383. https://doi.org/10.1016/j.biopha.2020.110383