Research

/Research
Research2019-01-18T16:43:50+00:00

Genomics Research


Group name: Biological Sequence Analysis (Head group: Gonzalo Riadi)

Participants

  • Gonzalo Riadi (PhD)
  • Braulio Valdebenito
  • Daniela Araya
  • Camilo Fuentes
  • Bairon Hernández
  • Matias Fuentes
  • Cristopher Fierro
  • Poliana Venegas

Research lines

  • Genomic Mobile Elements
  • Molecular Evolution

Informatics Research


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Computational Physical Chemistry


Group Name: No name (Head group: Jans Alzate-Morales)

Members

  • Ing. en Bioinformática Jocelyn Solorza Márquez, Asistente de Investigación
  • M.Sc. Rodrigo Recabarren Hurtado, Estudiante de Doctorado
  • Rubén Fritz Fritz, Estudiante de Doctorado
  • Q.F. Jefferson Romero Marulanda, Estudiante de Doctorado
  • Dra. Camila Muñoz Gutiérrez, Investigadora Postdoctoral

Research Lines

  • Computer Assisted Drug Design, protein engineering, enzyme catalysis

Funding

  • Investigador Principal, FONDECYT Regular No. 1181253, “Estimating residence time in protein-ligand complexes: New computational protocols for understanding binding kinetics of drugs.”
  • Investigador Patrocinante, FONDECYT Postdoctoral No. 3180321, “EVALUATION OF THE MOLECULAR STABILITY OF CYLINDRIN-LIKE STRUCTURES VIA MICROSECOND MOLECULAR DYNAMICS SIMULATIONS”.
  • Coinvestigador, FONDECYT Regular No. 1150615 “DESIGNING CHEMICAL POLY-BULLETS FOR NICOTINIC ACETYLCHOLINE RECEPTORS AND MONOAMINE TRANSPORTERS (SERT, NET AND DAT). A POLY-PHARMACOLOGY APPROACH TO UNDERSTAND THE NICOTINE ADDICTION AND WITHDRAWAL SYNDROME MEDIATED BY MULTIPLE RECEPT”.
  • Coinvestigador, FONDECYT Regular No. 1170662 “Multisteric drugs: Design of polypharmacological agents that simultaneously interact with monoaminergic proteins and nicotinic receptors, based on similarities between their multiple binding sites”.

Group name: Bio-nanomaterial Simulations group. (Head group Horacio Poblete)

Members

  • Horacio Poblete Vilches (PI)
  • Matias Zuñiga-Bustos (Post-Doc)
  • Constanza Galaz Araya (Undergraduate)
  • Roberto Rosales Rojas (Undergraduate)

Research Lines

  • Theoretical and Computational Biophysics: Predicting the adsorption of proteins onto nano-surfaces, using molecular dynamics and Free-energy calculation for inorganic/biological systems. Design of new bio-nanomaterials for bio-medicine applications.

Funding

  • Fondecyt Regular 2017, PI “New Insights into conformational equilibria of proteins absorbed to nanometal surfaces using molecular dynamics simulations: structural effects and protein camouflage applicable to nanomedicine.” Universidad de Talca. 2017 – 2021
  • Fondecyt Regular 2018, Co-Investigator:Horacio Poblete, PI: Jans Alzate-Morales “Estimating residence time in protein-ligand complexes: New computational tools for understanding the in-vivo pharmacological effects of drugs.” Universidad de Talca. 2018 – 2021
  • Millennium Nucleous 2017, Young Investigator “Millennium Nucleus of Ion Channels-Associated Diseases (MiNICAD).” Universidad de Talca. 2017 – 2021
  • Talca University Research support “Desarrollo Nucleo Cientifico Multidiciplinario” 2017-2020

Research Interests

  • Free-energy methods
  • Biophysics
  • Nanotechnology
  • Metal surfaces
  • Membrane dynamics
  • Ion channels
  • Transmembrane transporting.

Structural Biology


Group name: Plant Biophysics (Head group: Ingo Dreyer)

Participants

  • Ingo Dreyer (PhD)
  • Maria Rubio Melendez (PhD)
  • Carlos Navarro Retamal (PhD)
  • Naomí Hernández (undergraduate student)
  • Luisa Willmann (guest student)

Research lines

  • Computational plant cell biology
  • Electrical signaling in plants

Group name: Computational Structural Biology of Membrane Proteins (Head group: Ariela Vergara-Jaque)

Dr. Vergara-Jaque’s group uses sophisticated computational methodologies to study membrane proteins that function as channels and transporters. Our goal is to understand how membrane proteins rearrange their internal structure to allow or block the passage of specific substances to either side of the membrane. Moreover, we are interested in revealing the structural basis of protein−protein interactions regulating the function of membrane proteins.

Participants

  • Dr. Ariela Vergara-Jaque (Bioinformatics Engineer, PhD. in Applied Sciences): Group leader
  • Héctor Montecino (Bioinformatics Engineer): Research assistant
  • Ivana Orellana: Undergraduate thesis student
  • Genoveva Rojas: Undergraduate thesis student

Research interests

  • Sequence and structural bioinformatics, molecular modeling, protein−protein docking simulations, molecular dynamics, and free-energy calculations.

Funding

  • Fondecyt Research Initiation Grant Nº 11170223. Exploring the structural basis of membrane transporter dysfunction associated with neural and endocrine diseases. Principal Investigator.
  • Fondecyt Postdoctorate Nº 3180484. Heteroaryl-acrylonitrile derivatives as inhibitors of NADPH Oxidases in an isoform-specific manner. Sponsoring Researcher.
  • Millennium Nucleus of Ion Channels−Associated Diseases (MiNICAD). Young Investigator.

Collaborations

  • Dr. Miguel Holmgren. National Institute of Neurological Disorders and Stroke. National Institutes of Health, Maryland, USA.
  • Dr. Peying Fong. Department of Anatomy and Physiology, Kansas State University, College of Veterinary Medicine, Kansas, USA.
  • Dr. Tomas Lagace. Atherosclerosis, Genetics and Cell Biology Research Group, University of Ottawa Heart Institute, Ottawa, Canada.